👤 Personal Information
Full Names ryan oliver
GenderMale
Locationfairbanks, alaska (united states)
Birth Year—
💼 Professional Details
Job Titleassistant professor
Industryhigher education
Experience15 years
SummaryAll mammals depend on heat producing mechanisms to maintain body temperature. Skeletal muscle shivering and brown adipose tissue (BAT) uncoupling through the expression of uncoupling protein 1 (UCP-1) are the identified major sources of heat production, though recently, skeletal muscle has also been highlighted as a thermogenic source. Skeletal muscle nonshivering heat production occurs via sarcolipin (SLN) uncoupling of sarcoendoplasmic reticulum (SR) calcium ATPase (SERCA)-mediated ATP hydrolysis. My lab focuses on mechanisms of thermogenesis in a systems physiology approach to determine not only how mammals produce heat but also how multiple tissues communicate to regulate homeostatic temperatures. As humans also express SLN, the physiological mechanisms of these events provide insight toward a better understanding of metabolism within the context of temperature regulation and could expand our current understanding of thermoregulation in hibernating mammals, and eventually translate into future therapeutic developments for novel clinical treatments of obesity.
🛠 Skills
microscopy
cell
in vitro
physiology
confocal microscopy
molecular biology
immunohistochemistry
animal models
biology
laboratory
experimentation
metabolism
r
cell culture
cell biology
fluorescence microscopy
western blotting
biochemistry
pcr
flow cytometry
scientific writing
protein expression